DMR Release Notes

1. 21 Code of Federal Regulations (CFR) Part 11 Compliance
   • The PDBP DMR is fully certified and subsequently electronic records and electronic signatures within BRICS are considered trustworthy, reliable, and equivalent to paper records: 21CRFPart11 Certification
   • 21 CRF part 11 - eSignature: The user account creation process includes new functionality for acknowledging/signing a the new electronic signature policy
   • 21 CRF part 11 - system auditing: Improved user activity logging, capturing: 1) when a user has/is logged into the DMR; 2) how long the user is logged into the system; and 3) when the user is logged out. Access logs are available for review and download by system administrators in the Accounts Module
   • 21 CRF part 11 - ProFORMS Module updates: New "save & lock" eSignature acknowledgements, modifications to the collection audit log, mandatory write-up for change in collection/eForm, and capture of exact user name for locked forms in ProFoRMS to the Data Repository.
      
2. New Neuropathology Data Set (NACC Form Structure)
   • Addition of the NACC-Neuropathology Form Structure for brain data collection in the DMR Data Dictionary. To access the Form Structure, Click here. The Form is based on version 10 of the form. Note: This form is available for data collection in ProFoRMS. Users must submit data to this form using the Submission Tool available in the Data Repository. 
      
3. PDBP GUID Migration
   • As part of the centralized GUID solution, a collaborative effort between PDBP, NINDS, and NIA, all PDBP GUIDs (GUIDs & Pseudo-GUIDs) have been officially migrated to the centralized server. This allows for the potential of GUID sharing/visibility across PDBP, NINDS, and NIA, pending user permissions.
      
4. Query Tool - Performance Improvements
   • Improvements to the Query Tool Module include:
     • Significant performance improvements for data querying and form joins: system returns a 5-form join with approx. 1M records in ~20 seconds
     • Transition the Query Tool data-table to a Virtual Table to improve data rendering performance
     • Improvements to the Biosample Ordering process, allowing for a "select all" control for all or filtered biospecimen records
     • Replace data-table pagination with a single page view
        
5. Replacement of Mirth Web-services
   • Replacement of the older web-service (Mirth) that submitted ProFoRMS data to the Data Repository on a nightly basis to a newer, more efficient service

1. ProFoRMS Admin Privilege Removal
   • A status of "Active-Expiring Soon" caused ProFoRMS admin privileges to be removed from the Account Module
      
2. ProFoRMS - eForm retrieval issue
   • Permissions related to user access to the Data Dictionary and being able to retrieve/add eForms to a visit type
      
3. Number keypad disabled in GUID Module
   • Number pad on keyboard did not work with the GUID module. Attempting to interact with the GUID client and input participant information using the number pad was disabled

1. GUID Client Transition to JavaScript
   • Refactor of the current Java web-start client to a browser based, JavaScript application. This new feature will allow users the ability to generate GUIDs online The current Java (.jnlp file) application will be replaced, removing the need for users to download and install the GUID client each time they want to generate a GUID. The JavaScript version will load directly on the users page, allowing for faster, more efficient interactions with the GUID client. The GUID JavaScript application is supported on all browsers (Google Chrome, Firefox, Microsoft Edge, Safari, and Internet Explorer v10 and higher). All functionality from the previous webstart version is maintained
      
2. 5-Form Join Performance Improvements
   • Effort includes enhancing the speed and overall perform of returned queries for large form joins and resolving issues with large data packages being sent to the Download Tool
      
3. OpenJDK Alternative to Oracle Java
   • The inclusion of OpenJDK is intended to mitigate any potential issues regarding Oracle and Java license fees and/or support. OpenJDK will ensure that users are able to continue using BRICS webstarts (Download Tool, Submission Tool, MIPAV, etc.). For additional details on how to download and install OpenJDK, Click here.
      
4. Manage Protocol Using GUID or Subject ID
   • Allow protocol coordinators the ability to change GUID to Subject ID in Manage Protocols section in ProForms

1. Removal of Users from Account Permission Groups
   • Permission violation issue resolved for user account being removed from permissions groups
      
2. PDBP Public Site Anchors
   • Resolution of multiple URL anchors on the pdbp public site
      
3. PDBP Public Site - PubMed API
   • Refactor of the NHLBI PubMed API to automatically retrieve PDBP specific publications

1. Flag GUIDs with a Change in Diagnosis
   • This feature will highlight any/all GUIDs (records) in the Query Tool for subjects that have been identified as having a change in diagnosis. The process surveys the PDBP Change in Diagnosis form structure and highlights all GUIDs where the 'Change in Diagnosis' data element's permissible value is equal to "Yes." RDFGen has been modified to automate the highlight, removing the dependency on querying the specific PDBP Change in Diagnosis form structure and/or 'Change in Diagnosis' data element.
      
2. Query Tool 5-Form Join
   • This feature allows users the ability to join up-to five (5) form structures in the query tool. The previous configuration allowed for a maximum of three forms to be joined.
      
3. Multi-Tenant GUID Solution
   • This feature allows for the recognition and sharing of GUIDs across participating BRICS instances. Users can now 'link' GUID permissions across multiple instances and/or view 'matching' GUIDs across all instances. Pending permissions, users will be able to view the GUID along with specific meta-data including: Registered User; Registered Entity; and Date Registered. Further, this new feature has allowed for new, advanced database technologies to be incorporated (mongoDB), ensuring that the solution is scalable and secure.
      
4. Account Module Security Updates
   • In order to make the publicly available portions of BRICS more secure, additional controls are being added which include:
     • File upload limit - one file per upload type
     • File upload types - a restriction on file types (e.g. .pdf, .doc, etc.)
     • Implementation of reCAPTCHA to ensure requests are legitimate and being submitted by an actual user
        
5. jQuery Datatable Updates
   • Updating all BRICS data-tables and making them consistent across all modules. This release focused on the following modules/data-tables:
     • ProFoRMS - Reports tab (all), Collect Data tab (all), and Manage Protocol tab (all)
     • Biosample Order section (all)

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